Seminarios

Bioinformática estructural: del genoma a la droga. Dr. Adrián Turjanski

The advances of genomics, sequencing, and high throughput technologies have led to the creation of large volumes of diverse datasets for drug discovery. On the other hand algorithms developed by bioinformatitians are able to calculate a large set of protein properties such as function, structure, interactions, essentiality, resistance, and druggability. Ind this sense to develop new algorithms and to analyze these datasets to better undestand disease and discover new drugs is becoming increasingly necessary.

An increasing challenge is the reapid emergence of resistant bacteria that is occurring worldwide, endangering the efficacy of antibiotics.

Many decades after the first patients were treated with antibiotics, bacterial infections have again become a threat. Moreover, without effective antibiotics, the success of major surgery and cancer chemotherapy would be compromised.

In this seminar I will comment about our work on bacterial pathogens and how we are integrating data and developing tools that help to determine antibiotic resistance, identify key proteins to target and possible drugs to test in the wet lab.

Localización : Aula Cardini
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Dr. Adrián Turjanski.
Laboratorio de Bioinformática Estructural.
Departamento de Química Biológica, FCEN, UBA. IQUIBICEN-CONICET.

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